The effect of trial design on effect size with an assumed trial drug efficacy of 100% reduction in seizure burden for 72h (the maximum possible effect).

Outcome measures (OM) are total seizure burden (tSB) in minutes, post-intervention seizure burden (pSB) in minutes measured over a duration specified by the subscript in hours, seizure burden response (rSB) in minutes per hour, 1h pre-intervention vs. a post-intervention duration specified by the subscript in hours. The effect size of pSB1 and rSB1 are equal as the rSB is measured in minutes per hour and not as a proportion. Results are presented as effect size (95% CI).