TARGETED DELETION OF CELLULAR DNA SEQUENCES
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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资源简介：
Disclosed herein are methods and compositions for targeted deletion of double-stranded DNA. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain， and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins， or polynucleotides encoding same， into a cell such that two targeted cleavage events occur. Subsequent cellular repair mechanisms result in deletion of sequences between the two cleavage sites.
提供机构：
国家林业和草原科学数据中心
创建时间：
2023-02-12
