Comparison of bile acids and acetaminophen protein adducts in children and adolescents with acetaminophen toxicity

The relationship of individual bile acids to indicators of oxidative drug metabolism (acetaminophen protein adducts) and liver injury was examined in children with acetaminophen overdose, children with low dose exposure to acetaminophen, and children with no recent exposure to acetaminophen. Targeted metabolomic analysis was used to quantify nine bile acids in the serum samples of children and adolescents among the three groups. Bile acids were compared to serum levels of acetaminophen protein adducts and alanine aminotransferase.