Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434
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Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434 Descriptor: 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]te traazacyclotetradecin-8(3H)-one, CHLORIDE ION, MAGNESIUM ION, ... Authors: Wang, X, Liu, J, Zhang, W, Stashko, M.A, Nichols, J, DeRyckere, D, Miley, M.J, Norris-Drouin, J, Chen, Z, Machius, M, Wood, E, Graham, D.K, Earp, H.S, Graham, K, Kireev, D, Frye, S.V. Deposit date: 2016-05-17 Release date: 2017-01-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.545 Å) Cite: Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS Med Chem Lett, 7, 2016
原癌基因酪氨酸蛋白激酶MER（proto-oncogene tyrosine-protein kinase MER）催化结构域与抑制剂UNC2434结合的晶体结构
组分描述：15-{4-[(4-甲基哌嗪-1-基)甲基]苯基}-4,5,6,7,9,10,11,12-八氢-2,16-(氮杂亚甲基)吡咯并[2,1-d][1,3,5,9]四氮杂环十四烷-8(3H)-酮、氯离子、镁离子……
作者：Wang, X、Liu, J、Zhang, W、Stashko, M.A、Nichols, J、DeRyckere, D、Miley, M.J、Norris-Drouin, J、Chen, Z、Machius, M、Wood, E、Graham, D.K、Earp, H.S、Graham, K、Kireev, D、Frye, S.V.
保藏日期：2016-05-17
发布日期：2017-01-11
最后修改日期：2023-09-27
实验方法：X射线衍射（分辨率2.545埃）
引用文献：《新型大环类Mer酪氨酸激酶抑制剂的设计与合成》，《ACS药物化学通讯（ACS Medicinal Chemistry Letters）》，第7卷，2016年
创建时间：
2016-05-17
