BindingDB Entry 50049310: Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

Small molecule binding data for protein Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Macrophage colony-stimulating factor 1 receptor, Pancreatic endoplasmic reticulum kinase (PERK), SRC, Serine/threonine-protein kinase TAO2, Tyrosine-protein kinase BMX, Tyrosine-protein kinase JAK3, Tyrosine-protein kinase Lyn, VEGF-receptor 2 and Fibroblast growth factor receptor 1, VEGF-receptor 2 and Fibroblast growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot P07333, P07948, P11362, P21802, P22455, P22607, P35916, P35968, P51451, P51813, P52333, Q9NZJ5, and Q9UL54

本数据集包含针对下述蛋白质及蛋白复合物的小分子结合数据：成纤维细胞生长因子受体3、成纤维细胞生长因子受体4、黏着斑激酶1/血管内皮生长因子受体3、巨噬细胞集落刺激因子1受体、胰腺内质网激酶（PERK）、SRC、丝氨酸/苏氨酸蛋白激酶TAO2、酪氨酸蛋白激酶BMX、酪氨酸蛋白激酶JAK3、酪氨酸蛋白激酶Lyn、血管内皮生长因子受体2，以及三组蛋白组合：血管内皮生长因子受体2与成纤维细胞生长因子受体1、血管内皮生长因子受体2与成纤维细胞生长因子受体2、血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR与TIE2）。相关通用蛋白质数据库（UniProt）条目编号为：P07333、P07948、P11362、P21802、P22455、P22607、P35916、P35968、P51451、P51813、P52333、Q9NZJ5及Q9UL54。