Carpedilactones A–D, Four New Isomeric Sesquiterpene Lactone Dimers with Potent Cytotoxicity from <i>Carpesium faberi</i>
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Four new isomeric sesquiterpene lactone dimers, carpedilactones A–D (1–4), were isolated from the acetonic extract of Carpesium faberi. Among them, 1–3 are the first three 2,4-linked exo-Diels–Alder adducts between a eudesmanolide dienophile and a guaianolide diene. The absolute configurations of 1–4 were unambiguously established by Cu Kα X-ray crystallographic analyses. Compounds 1–4 exhibited potent cytotoxicities against human leukemia (CCRF-CEM) cells with IC50 value of 0.14, 0.32, 0.35, and 0.16 μM, respectively.
创建时间：
2016-02-17
