hALK in complex with ((1S,2S)-1-(2,4-difluorophenyl)-2-(2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy)cyclopropyl)methanamine

Protein Data Bank Japan2023-10-18 更新2026-03-21 收录

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hALK in complex with ((1S,2S)-1-(2,4-difluorophenyl)-2-(2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy)cyclopropyl)methanamine Descriptor: 1-{(1S,2S)-1-(2,4-difluorophenyl)-2-[2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl}methanamine, ALK tyrosine kinase receptor Authors: McGrath, A.P, Zou, H, Lane, W, Saikatendu, K. Deposit date: 2020-08-28 Release date: 2021-01-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design. Acs Omega, 5, 2020

人源ALK（hALK）与((1S,2S)-1-(2,4-二氟苯基)-2-(2-(3-甲基-1H-吡唑-5-基)-4-(三氟甲基)苯氧基)环丙基)甲胺形成的复合物描述项：1-{(1S,2S)-1-(2,4-二氟苯基)-2-[2-(3-甲基-1H-吡唑-5-基)-4-(三氟甲基)苯氧基]环丙基}甲胺，ALK酪氨酸激酶受体作者：McGrath, A.P.、Zou, H.、Lane, W.、Saikatendu, K. 提交日期：2020-08-28 发布日期：2021-01-20 最后修改日期：2023-10-18 实验方法：X射线衍射（2.42 Å）引用文献：《通过片段辅助基于结构的药物设计发现新型高选择性环丙烷类ALK抑制剂》，发表于《ACS Omega》2020年第5卷

创建时间：

2020-08-28