Au-Catalyzed Asymmetric Formal [3 + 2] Cycloaddition of Isocyanoacetates with Maleimides
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https://figshare.com/articles/dataset/Au_Catalyzed_Asymmetric_Formal_3_2_Cycloaddition_of_Isocyanoacetates_with_Maleimides/2529313
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资源简介：
An efficient protocol for the AuI-catalyzed
asymmetric
formal [3 + 2] cycloaddition of isocyanoacetates with phenylmaleimide
has been developed. In the presence of cationic AuI/DTBM-segphos
complex, excellent diastereoselectivity and high levels of enantioselectivity
(up to 97% ee) have been attained with a variety of α-substituted
isocyanoacetates. The synthetic potential of the resulting enantioenriched
1-pyrrolines has been demonstrated by the preparation of highly substituted
pyrrolidines bearing a quaternary stereocenter.
创建时间：
2012-04-20
