Structure of SARS-CoV-2 D614G Spike Protein with Engineered x3 Disulfide (x3(D427C, V987C) and single Arg S1/S2 cleavage site), Locked-2 Conformation

Structure of SARS-CoV-2 D614G Spike Protein with Engineered x3 Disulfide (x3(D427C, V987C) and single Arg S1/S2 cleavage site), Locked-2 Conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... Authors: Qu, K, Chen, Q, Ciazynska, K.A, Liu, B, Zhang, X, Wang, J, He, Y, Guan, J, He, J, Liu, T, Zhang, X, Carter, A.P, Xiong, X, Briggs, J.A.G. Deposit date: 2022-05-18 Release date: 2022-07-20 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike. Plos Pathog., 18, 2022

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）D614G刺突蛋白的结构：该蛋白携带工程化三二硫键（x3(D427C, V987C)）以及单精氨酸S1/S2切割位点。锁定-2构象描述组分包括：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose）、胆绿素IXα（BILIVERDINE IX ALPHA）等。作者：Qu, K、Chen, Q、Ciazynska, K.A、Liu, B、Zhang, X、Wang, J、He, Y、Guan, J、He, J、Liu, T、Zhang, X、Carter, A.P、Xiong, X、Briggs, J.A.G.。存档日期：2022-05-18；发布日期：2022-07-20；最后修改日期：2025-07-02。实验方法：电子显微镜（分辨率3.2 Å）。引用文献：《工程化二硫键揭示锁定型严重急性呼吸综合征冠状病毒2刺突蛋白的结构动态》，刊载于《PLOS Pathog.》，2022年，第18卷。