Cell wall proteome profiling of a Candida albicans fluconazole-resistant strain from a Lebanese hospital patient

In this pilot study we employed a tandem mass
spectrometry approach coupled with a bioinformatics approach to identify cell wall
proteins present in a fluconazole-resistant Candida albicans hospital isolate upon drug
exposure. The isolate was previously shown to have an increase in cell membrane
ergosterol and cell wall chitin, alongside an increase in adhesion, but
slightly attenuated in virulence. The file generated by the MALDI-TOF-TOF analyzer was searched in MASCOT Server and yielded a peptide summary report including all identified proteins. Those MALDI and MASCOT files are presented here. The unmatched peptides in the peptide summary report were also identified using BLAST search in Candida Genome Database.