A biomarker-based database system for early diagnosis of nasopharyngeal carcinoma (NPC-BM)

According to the World Cancer Report 2020 published by the World Health Organization's Institute for Research on Cancer (IARC), there will be 19.29 million new cancer cases and 9.96 million deaths globally in 2020, of which 4.569 million new cases and 3.003 million deaths will occur in China, accounting for 23.7% and 30.2% of the global new cases and deaths, respectively. Among them, China had 4.569 million new cancer cases and 3.003 million deaths, accounting for 23.7% and 30.2% of the global new cases and deaths respectively. China has become the largest country in the world in terms of new cancer cases and deaths.Nasopharyngeal cancer is a kind of malignant tumor with a very high clinical incidence rate, and it is at the top of the list of malignant tumors in otorhinolaryngology. Due to the deep and hidden nasopharyngeal part, the complex relationship with the surrounding area, and the differences in clinical manifestations, early diagnosis is very difficult, and it is very easy to miss the optimal time of treatment due to missed or misdiagnosis. Due to the unique anatomical location and tumor biological behavior of nasopharyngeal cancer, simultaneous radiotherapy has been the main treatment for nasopharyngeal cancer, followed by radiotherapy, chemotherapy, targeted therapy, surgery, and traditional Chinese medicine.Early tumor diagnosis refers to the use of rapid and easy methods to screen out a very small number of tumor high-risk groups from a large number of target populations that appear healthy and have not yet developed symptoms, which can detect tumors early and reduce the risk of morbidity, especially for cancer types with high morbidity and mortality rates and a long developmental cycle, such as lung, gastric, and colorectal cancers. From a global perspective, China's cancer incidence and mortality rates are at a high level, and there are multiple reasons for this phenomenon - medical technology needs to be improved, the quality of the living environment is poor, the routine of life is irregular, and living habits are poor. Compared with chronic diseases such as cardiovascular disease and diabetes, tumor is a "fatal disease" that requires early diagnosis and treatment, and the earlier the diagnosis, the greater the hope of cure. To integrate the data resources and results of early diagnosis of nasopharyngeal cancer and to promote related research, a literature review and information extraction analysis were carried out, and a biomarker-based early diagnosis database of nasopharyngeal cancer was constructed to assist the early diagnosis of nasopharyngeal cancer. The database covers the types of biomarkers, name, specificity, sensitivity, AUC, cell lines used, sample type, sample size, references, and their links. The database contains many types of biomarkers and is a powerful tool for early screening and diagnosis of nasopharyngeal cancer.