USP17L2 deubiquitinates RCE1
收藏reactome.org2025-03-23 收录
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USP17L2, also known as USP17, deubiquitinates RCE1 (RAS-converting enzyme 1), inactivating it. Loss of RCE1 activity after USP17L2-mediated deubiquitination interferes with RAS localization and function and prevents downstream signaling through the RAF MAP kinase cascade (Burrows et al, 2009).
USP17L2,亦称USP17,通过去泛素化RCE1(RAS转化酶1)使其失活。USP17L2介导的去泛素化作用导致RCE1活性丧失,干扰RAS的定位和功能,并阻止下游信号通过RAF MAP激酶级联反应(Burrows等人,2009年)。
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