Transcriptional characterization of cardiac tissue of rat pups with pulmonary banding

NIAID Data Ecosystem2026-03-12 收录

心脏转录组分析

肺动脉高压

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE143745 数据链接链接失效反馈

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资源简介：

Expression analysis of cardiac tissue of rat pups with and without pulmonary banding RNA-seq on rat tissue

创建时间：

2021-07-31

Analysis of lung transcriptome of Mice under normoxia or hypoxia conditions and treated with ABT-263 or its vehicle during 8 days

肺动脉高压

衰老细胞清除

To explore the role played by senescent cells in mice models of pulmonary hypertension we exposed young C57BL6/j mice to 8 days hypoxia or normoxia and treated with senolytic drug ABT-263 (50mg/kg/day

NIAID Data Ecosystem90

MOESM6 of Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling

肺动脉高压

细胞外基质基因表达

Additional file 6: Table S5. Gene Ontology enrichment analysis for Biological Process using differential RNAs found in TGF-β1 treated HPASMC-EVs. (XLSX 17 kb)

NIAID Data Ecosystem50

Verification of the hypoxia-induced PAH model in rats in this study.

肺动脉高压

低氧生理实验

Norm: normal group n = 10, Hypo: Hypoxia group n = 10; RVSP: Right ventricular systolic pressure, mPAP mean pulmonary artery pressure, RV/(LV+S): right ventricle to left ventricle plus septum. Table 1

NIAID Data Ecosystem30

Phospholamban Antisense Oligonucleotides Improve Cardiac Function in Murine Cardiomyopathy

心肌病基因治疗

心脏转录组分析

Heart failure (HF) is a major cause of morbidity and mortality worldwide, but therapeutic intervention remains limited despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathop

NIAID Data Ecosystem70

Fcer1a全身敲除并建立低氧诱导小鼠肺动脉高压模型实验数据集

肺动脉高压

免疫学

全身敲除Fcer1a后建立低氧诱导肺动脉高压模型，对照组小鼠为WT小鼠。低氧建模4周后在体进行心动超声检测，测量小鼠肺动脉血流多普勒。随后取材检测小鼠RVSP，RVHI，病理衡量小鼠肺血管厚度和肌化程度。实验结果显示敲除IgE受体Fcer1a可以缓解低氧所致肺动脉高压和肺血管重塑。

国家人口健康科学数据中心30