Spatial distribution of fractionally administered holmium microspheres in non-tumorous human liver tissue: how livers survive transarterial radioembolisation

Background: Relatively high mean absorbed doses to the non-tumorous liver tissue (NTLT) are generally well tolerated in transarterial radioembolisation (TARE), potentially due to a heterogeneous dose distribution. This study investigates the macroscopic and microscopic distribution of fractionally administered TARE holmium microspheres in NTLT using an experimental setup of ex vivo perfused human donor livers under magnetic resonance imaging (MRI), and validates these findings through a comparison with MRI data from TARE-treated patients.

The collection contains:
Folder 'MATLAB_scripts':
- HeterogeneityAnalysis.m;
MATLAB script to analyse the dose maps.
- FluorescenceMicroscopyAnalysis.m;
MATLAB script to analyse the fluorescence microscopy images.
- CalculateMicrosphereConcentration.m;
MATLAB script to calculate the microsphere concentration (i.e. the amount of microspheres in mg per ml of tissue volume) from the activity concentration maps.

Folder 'Raw_data':
1. Experiment protocol;
2. Imaging data:
a) MRI data;
b) Dose maps;
c) Segmentations;
d) Fluorescence microscopy data;
3. Results:
a) HeterogeneityAnalysis;
b) FluorescenceMicroscopyAnalysis.

Used software: Q-suite (version 2.2, Quirem Medical B.V., Deventer, The Netherlands), Matlab R2023b (MathWorks, Natick, Massachusetts, USA).