The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-one

The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-one Descriptor: (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-(2-methoxyethoxy)-3-(2-methoxyethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Bischoff, M, Sippel, C, Bracher, A, Hausch, F. Deposit date: 2014-07-02 Release date: 2014-10-15 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.03 Å) Cite: Stereoselective Construction of the 5-Hydroxy Diazabicyclo[4.3.1]decane-2-one Scaffold, a Privileged Motif for FK506-Binding Proteins. Org.Lett., 16, 2014

FKBP51的Fk1结构域与(1S,5S,6R)-10-[(3,5-二氯苯基)磺酰基]-5-(2-甲氧基乙氧基)-3-(2-甲氧基乙基)-3,10-二氮杂双环[4.3.1]癸烷-2-酮形成的复合物。描述项：(1S,5S,6R)-10-[(3,5-二氯苯基)磺酰基]-5-(2-甲氧基乙氧基)-3-(2-甲氧基乙基)-3,10-二氮杂双环[4.3.1]癸烷-2-酮、肽基脯氨酰顺反异构酶（Peptidyl-prolyl cis-trans isomerase）FKBP5。作者：Bischoff M、Sippel C、Bracher A、Hausch F。沉积日期：2014-07-02；发布日期：2014-10-15；最后修改日期：2023-12-20。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.03 Å。引用文献：《5-羟基二氮杂双环[4.3.1]癸烷-2-酮骨架的立体选择性构建——FK506结合蛋白（FK506-Binding Proteins）的优势基元》，发表于《有机快报》（Org.Lett.），第16卷，2014年。