Raw Data for Figure 2

Water and food intake in TRPV4 WT and KO mice before and after induction of endotoxaemia. Basal water intake was measured in TRPV4 WT and KO mice over approximately 1 week (not including 7-day recovery period from telemetry surgery). Change in water intake was measured over 24-h period following i.p. administration of either vehicle (10% DMSO) or HC-067047, as well as during the 24-h period following administration of LPS (12.5 mg/kg i.v.). Basal food intake in TRPV4 WT and KO mice was measured over approximately 1 week (not including 7-day recovery period from telemetry surgery). Change in food intake was measured over 24-h period following i.p. administration of either vehicle (10% DMSO) or HC-067047, as well as during the 24-h period following administration of LPS (12.5 mg/kg i.v.).