Comparative transcriptomic study of skeletal muscles response to muscular dystrophy with myositis

Muscular dystrophy with myositis (mdm) is a severe degenerative muscle disease arising from a spontaneous mutaton at the N2A-PEVK junction of titin protein. The affected mice show a complex disease phenotype, and more organism-wide spread response compared to other myopathies. The project objectives forcus on undertanding the response pattetern of different skelelal muscles to mdm. Overall design: Examin the transcriptomic resposne of mdm afected skeletal muscle compared to wildype in the B6C3Fe a/a-Ttnmdm/J +/+ mice