Comparison of the effects on tumorigenicity and the microenvironment of inhibiting different fibroblast-secreted factors.

Summary of results obtained from tumorigenicity assays and immunohistochemical characterization of the tumor microenvironment in AREG, CCL2, CCL7, CCL8 and STC1 silenced tumors compared to non-target control. Three major parameters, namely total area under the curve (AUC), endpoint tumor volume (week 6 post injection) and immunohistochemistry of tumor microenvironment were used to quantify differences between the control and experimental groups.