Single-cell immune cell–resolved Mendelian randomization identifies a protective causal role of complement factor D in CD4⁺KLRB1⁻ T cell against small cell lung cancer risk

Supplementary File 1. Paraptosis-related gene set curation and instrument summary (eQTLGen/GTEx/OneK1K). Supplementary File 2. Full MR screening results and sensitivity diagnostics for the eQTLGen stage. Supplementary File 3. GTEx v10 whole-blood eQTL exposure data extraction for validation candidates. Supplementary File 4. GTEx-based instrument construction details. Supplementary File 5. Validation MR estimates and robustness outputs using GTEx whole-blood instruments. Supplementary File 6. Differential expression results for CFD (and comparator genes) across four GEO cohorts. Supplementary File 7. OneK1K PBMC single-cell eQTL exposure files for 14 immune cell types. Supplementary File 8. Single-cell instrument selection and LD processing per immune cell type. Supplementary File 9. Immune cell–resolved MR results and sensitivity analyses across immune subsets.