Exploiting Multi-Omics Profiling And Systems Biology to Investigate Functions of TOMM34

Here, we report genes and pathways associated with TOMM34, Translocase of OuterMitochondrial Membrane which plays role in the mitochondrial protein import as a part of cytosoliccomplex together with Hsp70/Hsp90 and upregulated in various cancers. We identified genes,proteins and metabolites altered in TOMM34 -/- HepG2 cells. To our knowledge, this is the firstattempt to study the functional capacity of TOMM34 using a multi-omics strategy.

本报告揭示了与TOMM34（外线粒体膜转运蛋白复合物）相关的基因和通路，TOMM34在作为细胞质复合物的一部分参与线粒体蛋白导入过程中发挥着重要作用，并在多种癌症中呈上调状态。本研究识别了在TOMM34-/- HepG2细胞中发生改变的基因、蛋白质和代谢物。据我们所知，这是首次尝试采用多组学策略研究TOMM34的功能潜力。