New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia

Raw data associated to the paper Zanardi, Nardini, et al. Communications Biology (see link).
- Proteomics raw data for protein identification associated to Figure 1 of the manuscript are deposited in dedicated repository indicated in the paper (see "link")
- Folder " 64CUkCP Biodistribution ": raw data associated to Fig 5 panel (a) and Supplementary Figure 8 describing labelled Cp biodistribution in the brain and blood of mice
- Folder "Images choroid plexus": collection of the histochemistry images of choroid plexus stained for iron deposition used to generate data of figure 5 panels (g and h)
- Folder "Images Purkinje": collection of the histochemistry images of cerbellum used to count thenumber of Purkinje neurons reported on figure 5 panels (i and j)
- Folder "Images liver": collection of the histochemistry images of liver stained with hematoxylin-eosin used to generate figure 7 panels (c and d)
- Folder Immunohistochemistry images Cerebellum => Autofluor Purkinje Cells Density: images used to generate data in figure 5 panels (k and l)
- Folder Immunohistochemistry images Cerebellum => Astrocyte Density in Arbor Vitae: images used to generate data in figure 6 panels (a and b)
- Folder Immunohistochemistry images Cerebellum => GFAP expression in Arbor Vitae: images used to generate data in figure 6 panel (c)
- Folder Immunohistochemistry images Cerebellum => Microglia Density in Arbor Vitae: images used to generate data in figure 6 panels (a and d)
- Folder Immunohistochemistry images Cerebellum => IBA1 expression in Arbor Vitae: images used to generate data in figure 6 panel (e)
- Folder Immunohistochemistry images Hippocampus => Astrocyte Density in CA1 SR: images used to generate data in figure 6 panels (f and g)
- Folder Immunohistochemistry images Hippocampus => GFAP expression in CA1 SR: images used to generate data in figure 6 panel (h)
- Folder Immunohistochemistry images Hippocampus => Microglia Density in CA1 SR: images used to generate data in figure 6 panels (i and j)
- Folder Immunohistochemistry images Hippocampus => IBA1 expression in CA1 SR: images used to generate data in figure 6 panel (k)
- Folder Immunohistochemistry images Hippocampus => Neuron Density in CA1 SP: images used to generate data in figure 6 panels (l and m)
- Folder Immunohistochemistry images Hippocampus => Thickness of CA1 SP: images used to generate data in figure 6 panel (n)
- Folder Immunohistochemistry images Hippocampus => Autofluor Neurons Density in CA1 SP: images used to generate data in figure 6 panel (o)
- Folder "WT+CP database ": raw data associated to Supplementary Figure 6 describing the evaluation of toxicity induction in wild-type (WT) mice treated for 4 months with purified ceruloplasmin

与论文《Zanardi, Nardini 等人，通讯生物学》（参见链接）相关的原始数据集已存档于文中指定的专用存储库（参见“链接”）。具体数据如下：
- 文件夹“64CUkCP Biodistribution”：包含与图5（a）和补充图8相关的原始数据，该图描述了标记的Cp在大鼠脑部和血液中的生物分布。
- 文件夹“Images choroid plexus”：包含用于生成图5（g和h）数据的脉络丛铁沉积的染色组织化学图像。
- 文件夹“Images Purkinje”：包含用于统计图5（i和j）中Purkinje神经元数量的小脑染色组织化学图像。
- 文件夹“Images liver”：包含用于生成图7（c和d）数据的肝组织化学图像，该图像使用苏木精-伊红染色。
- 文件夹“Immunohistochemistry images Cerebellum => Autofluor Purkinje Cells Density”：包含用于生成图5（k和l）数据的图像。
- 文件夹“Immunohistochemistry images Cerebellum => Astrocyte Density in Arbor Vitae”：包含用于生成图6（a和b）数据的图像。
- 文件夹“Immunohistochemistry images Cerebellum => GFAP expression in Arbor Vitae”：包含用于生成图6（c）数据的图像。
- 文件夹“Immunohistochemistry images Cerebellum => Microglia Density in Arbor Vitae”：包含用于生成图6（a和d）数据的图像。
- 文件夹“Immunohistochemistry images Cerebellum => IBA1 expression in Arbor Vitae”：包含用于生成图6（e）数据的图像。
- 文件夹“Immunohistochemistry images Hippocampus => Astrocyte Density in CA1 SR”：包含用于生成图6（f和g）数据的图像。
- 文件夹“Immunohistochemistry images Hippocampus => GFAP expression in CA1 SR”：包含用于生成图6（h）数据的图像。
- 文件夹“Immunohistochemistry images Hippocampus => Microglia Density in CA1 SR”：包含用于生成图6（i和j）数据的图像。
- 文件夹“Immunohistochemistry images Hippocampus => IBA1 expression in CA1 SR”：包含用于生成图6（k）数据的图像。
- 文件夹“Immunohistochemistry images Hippocampus => Neuron Density in CA1 SP”：包含用于生成图6（l和m）数据的图像。
- 文件夹“Immunohistochemistry images Hippocampus => Thickness of CA1 SP”：包含用于生成图6（n）数据的图像。
- 文件夹“Immunohistochemistry images Hippocampus => Autofluor Neurons Density in CA1 SP”：包含用于生成图6（o）数据的图像。
- 文件夹“WT+CP database”：包含与补充图6相关的原始数据，该图描述了经纯化铜蓝蛋白治疗4个月的野生型（WT）小鼠的毒性诱导评估。