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Direct Catalytic Asymmetric Synthesis of β‑Hydroxy Acids from Malonic Acid

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https://figshare.com/articles/dataset/Direct_Catalytic_Asymmetric_Synthesis_of_Hydroxy_Acids_from_Malonic_Acid/2097556
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资源简介:
A nickel­(II) catalyzed asymmetric synthesis of β-hydroxy acids from malonic acid and ketones was developed, revealing for the first time the synthetic utility of malonic acid in the construction of chiral carboxyl acids; importantly, the synthetic potential of this strategy was further demonstrated by the rapid construction of cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.
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2016-02-12
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