Sensitivity analyses with different definitions of drug exposures.

Association between benzodiazepine prescribing in the first trimester of pregnancy and the risk of major congenital anomalies in offspringa.aChildren born to women without depression or anxiety as the comparison group & gaps in the table indicated insufficient data available for the specific comparisons.bDoes not include children born to women with co-prescriptions of antidepressants in the first trimester of pregnancy.cChildren born to women prescribed diazepam, temazepam, or zopiclone without other benzodiazepine or non-benzodiazepine hypnotics.dChildren born to women with at least one high-dose prescription (defined as 15 mg or above per day for diazepam, 20 mg or above per day for temazepam and 7.5 mg or above per day for zopiclone).eChildren born to women with at least two prescriptions of each individual drug.AOR = odds ratio adjusted for maternal age at childbirth, calendar year at birth at a categorical variables, maternal smoking, body mass index and socioeconomic status.MCAs = major congenital anomalies; CI = confidence interval.