Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 4-(((6-Bromo-1H-indazol-4-yl)amino)methyl)phenol (2)

Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 4-(((6-Bromo-1H-indazol-4-yl)amino)methyl)phenol (2) Descriptor: 4-[[(6-bromanyl-1~{H}-indazol-4-yl)amino]methyl]phenol, ACETIC ACID, Indoleamine 2,3-dioxygenase 1, ... Authors: Li, G.-B, Ning, X.-L. Deposit date: 2021-01-28 Release date: 2021-07-21 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.635 Å) Cite: X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. J.Med.Chem., 64, 2021

人类吲哚胺2,3-双加氧酶1（hIDO1）与4-[[(6-溴-1H-吲唑-4-基)氨基]甲基]苯酚（化合物2）的复合物晶体结构。组分：4-[[(6-溴-1H-吲唑-4-基)氨基]甲基]苯酚、乙酸、吲哚胺2,3-双加氧酶1……作者：Li, G.-B、Ning, X.-L. 提交日期：2021-01-28；发布日期：2021-07-21；最后修改日期：2024-10-16。实验方法：X射线衍射（分辨率2.635 Å）。引用文献：《X射线结构导向发现一种强效、口服生物可利用的双重人吲哚胺/色氨酸2,3-双加氧酶（hIDO/hTDO）抑制剂，在帕金森病小鼠模型中显示活性》，《药物化学杂志》，2021年，第64卷。