Crystal structure of human acetylcholinesterase in complex with C35.
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Crystal structure of human acetylcholinesterase in complex with C35. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Dias, J, Nachon, F. Deposit date: 2017-11-23 Release date: 2018-12-12 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3.05199647812 Å) Cite: New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease. Neuropharmacology, 155, 2019
人乙酰胆碱酯酶（human acetylcholinesterase）与C35复合物的晶体结构。配体描述：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→3)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose）……
作者：Dias, J、Nachon, F
提交日期：2017-11-23，发布日期：2018-12-12，最后修改日期：2024-10-23
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率3.05199647 Å）
引用文献：《乙酰胆碱酯酶双结合位点抑制剂作为阿尔茨海默病治疗改良药物的新证据》，《神经药理学》，第155卷，2019年
创建时间：
2017-11-23
