Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with isoorotic acid (2,4-Dihydroxypyrimidine-5-carboxylic Acid), Form I

Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with isoorotic acid (2,4-Dihydroxypyrimidine-5-carboxylic Acid), Form I Descriptor: 1,2-ETHANEDIOL, 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, Uracil-DNA glycosylase Authors: Raj, P, Paul, A, Gopal, B. Deposit date: 2023-01-27 Release date: 2023-07-12 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. Eur.J.Med.Chem., 258, 2023结核分枝杆菌尿嘧啶DNA糖苷酶（Uracil-DNA glycosylase）与异乳清酸（2,4-二羟基嘧啶-5-羧酸）结合复合物的晶体结构，晶型I。成分描述：1,2-乙二醇、2,4-二氧代-1,2,3,4-四氢嘧啶-5-羧酸、尿嘧啶DNA糖苷酶。作者：Raj P、Paul A、Gopal B。沉积日期：2023年1月27日；发布日期：2023年7月12日；最后修改日期：2024年5月8日。实验方法：X射线衍射（分辨率1.72埃）。引用文献：《以与结核分枝杆菌尿嘧啶DNA糖苷酶（MtUng）结合的非尿嘧啶环片段的晶体结构作为新型抑制剂设计的起点：以巴比妥酸片段为例》，Eur.J.Med.Chem., 258, 2023