Transcriptome-wide analysis of hidradenitis suppurativa

The aim of this study was to obtain a better understanding of the molecular background of hidradenitis suppurativa (HS). Global transcriptome analysis of lesional and perilesional skin identifies numerous differentially expressed genes that display unique expression pattern in HS. Genes, whose expression is dysregulated in the skin of patients suffering from HS are novel biomarker candidates and potential therapeutic targets for HS. Overall design: RNA-seq was performed to analyse transcriptome of perilesional and lesional skin of five hidradenitis suppurativa patients and six controls.