QoVAX Statewide: Long-term COVID-19 Study in adults aged 18 years and older living in Queensland, Australia

The overarching primary research question for the QoVAX SET Statewide study is: In the Queensland community statewide, what level of short-term vaccine humoral immunity induced at one to three months post vaccination is associated with i) protection from community acquired SARS-CoV-2 infection with known or emergent variants of concern, and ii) severe health outcomes of community acquired COVID-19. The QoVAX Statewide study will address these specific research questions; 1. What are the host intrinsic (level of antibody response, HLA type) and extrinsic factors (socio-economic health determinants, environmental exposures e.g. smoking) associated with i) vaccine efficacy, and ii) severe COVID-19? 2. Do members of the community who identify as Aboriginal and/or Torres Strait and/or South Sea Islander, or as being from diverse ethnic backgrounds, show similar vaccine responses, and associations with i) vaccine efficacy, and ii) severe COVID-19, and the general Queensland population? 3. Do certain pre-existing health conditions (autoimmunity, cancer, immunodeficiency), and medication use effect i) vaccine efficacy, and ii) vulnerability to severe COVID-19? A statewide recruitment campaign will be undertaken and participants will self-enroll via the study website. A questionnaire will be completed and blood samples collected at 1 - 3 months following the last dose of a COVID-19 vaccine or at enrollment for unvaccinated participants. Participants will be followed over the long term via both repeat questionnaires and data linkage with administrative health datasets to ascertain study outcomes. (2023-04-19)

QoVAX SET全州研究的核心首要研究问题为：在昆士兰州全域社区范围内，接种新冠疫苗后1至3个月诱导产生的短期体液免疫（humoral immunity）水平，分别与以下两者存在何种关联：① 对已知或新兴关切变异株引发的社区获得性SARS-CoV-2（严重急性呼吸综合征冠状病毒2）感染的保护效力；② 社区获得性COVID-19（新型冠状病毒肺炎）的重症健康结局。
本研究将针对以下具体研究问题展开探索：
1. 哪些宿主内在因素（抗体应答水平、人类白细胞抗原（HLA）分型）与外在因素（社会经济健康决定因素、吸烟等环境暴露），分别与① 疫苗保护效力，以及② COVID-19重症风险相关？
2. 自认为属于原住民和/或托雷斯海峡岛民和/或南岛民（South Sea Islander），或来自多元族裔背景的社区人群，其疫苗应答情况、与① 疫苗保护效力及② COVID-19重症的关联模式，是否与昆士兰州普通人群一致？
3. 特定基础健康状况（自身免疫性疾病、癌症、免疫缺陷）及用药情况，是否会影响① 疫苗保护效力，以及② 发展为COVID-19重症的易感性？
本研究将开展全域招募，参与者可通过研究官网自主报名入组。所有参与者需填写调研问卷，并于完成最后一剂新冠疫苗接种后1至3个月采集血样；未接种新冠疫苗的参与者则于入组时采集血样。研究团队将通过重复问卷调研与行政健康数据集关联分析两种方式对参与者进行长期随访，以明确研究结局。(2023-04-19)