Targeted Metabolomics in the REGARDS Stroke Case-Cohort Study

Targeted Metabolomics in the REGARDS Stroke Case-Cohort Study. A prospective
epidemiological study with a case-cohort design. Targeted metabolomics was
conducted on plasma samples from a nested case-cohort study within the bi-
racial REasons for Geographic and Racial Differences in Stroke (REGARDS), a
longitudinal prospective cohort. The REGARDS study was designed to investigate
different health outcomes with a focus on stroke disparities across the USA.
Participants were oversampled from the Southeastern regions of the "stroke
belt," where stroke risk and mortality are 2-4 times higher in the African
American population. The study recruited 30,239 community-dwelling Black and
White participants aged 45 years or older. Plasma samples were collected
during the baseline study visit between 2003 and 2007 and stored at -80°C.
This dataset includes a total of 2,378 plasma samples representing the stroke
case-cohort sub-study. Participants of the random cohort (N=1,056) were
selected at the point of enrolment. Stroke cases were adjudicated up to April
2009 (N=1,322).