Interaction of selected kinases with RRM1-dependent gemcitabine efficacy.
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*The IC50 ratio was calculated by dividing the siRNA-specific IC50 by the control IC50. Cell lines H23, MCF7, and H1299 were exposed to gemcitabine for four 4 days. H125, H650, H1648, and H2122 were exposed for 5 to 7 days (a 4-day exposure yields IC50 values above 1 mM). RRM1 knockdown in the gemcitabine resistant clones restored sensitivity (IC50 ratios: 0.15 for H23-G-C8 and H23-G-C23, 0.19 for H1299-G-C2 and 0.09 for H1299-G-C18).
创建时间：
2013-03-04
