Whole-exome sequencing of Fancc-/-;Mad2+/- mouse leukemia

To examine genomic instability in four Fancc-/-; Mad2+/- malignancies, we performed whole-exome sequencing (WES) coupled with copy number variation (CNV) analysis. These studies provided initial insights into the somatic evolution of hematopoietic genome instability in Fancc-/-; Mad2+/- mice as they progress towards MDS/AML.