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Articulo 022 Total Chemical Synthesis of HKE2.pdf

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HRA Figshare2026-03-16 更新2026-07-03 收录
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The total synthesis of hemiketal E2 (HKE2) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE2. Synthetic hemiketal E2 reproduced biosynthetically derived HKE2 in the inhibition of human platelet aggregation

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2019-04-14
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