VIPVIZA VIsualiZation of asymptomatic Atherosclerotic disease for optimum cardiovascular prevention ─ a randomized controlled trial nested in the Västerbotten Intervention Program - Psychological factors and reactions to the VIPVIZA intervention (Problem management), 3 years

The aim of the project is to develop better methods for prevention of cardiovascular diseases (CVD). It is based on the hypothesis that image-based information on subclinical atherosclerosis (i) increases the precision in the assessment of risk of CVD, (ii) improves communication and understanding of the risk, and as a consequence (iii) the motivation for and adherence to evidence-based pharmacological treatment and lifestyle modification will increase. In addition to conventional risk factor assessment and CVD prevention within the framework of Västerbotten Intervention Program. 3500 healthy participants with low/moderate risk of CVD underwent ultrasound examination of the carotid arteries and were randomized to two groups. In the intervention group, the participants and their doctors received pictorial and graphic information in color about the participant’s subclinical atherosclerosis. No information about the ultrasound results was given to the control group. Follow-up after 1, 3 and 6.5 years includes sampling regarding clinical risk factors, blood for biomarker analyses, extensive questionnaires and interviews. At 3 and 6.5 years the ultrasound examination was repeated and all participants and their doctors were informed about the results. The database also includes register data regarding prescriptions of preventive medication, exposure data for air pollutants, data from health examinations within the VIP 10 and 20 years before VIPVIZA, and for men conscription data. After 10 years, registry data on endpoints, CVD morbidity and mortality will be collected. Access to VIPVIZA's data portal and research data from VIPVIZA is possible in collaboration with researchers within the VIPVIZA project. For further information, contact PI Ulf Näslund [e-mail] Validated questionnaires on psychological factors of importance for the development of CVD. Examples: Health literacy, anxiety/depression, coping mechanisms, general self efficacy, stress/burnout, optimism/pessimism, self-rated risk of CVD, Burnout. Self-rated risk of CVD, specific self efficacy, attitudes to life style habits Intervention group: Reactions to and impact of the ultrasound report本项目旨在开发更优化的心血管疾病（Cardiovascular Diseases, CVD）预防方法。本研究基于以下假设：与亚临床动脉粥样硬化（subclinical atherosclerosis）相关的影像信息，(i) 可提升心血管疾病风险评估的精准度，(ii) 能改善对疾病风险的沟通与理解，进而(iii) 提升受试者遵循循证药物治疗与生活方式干预的动机与依从性。本研究在北博滕干预计划（Västerbotten Intervention Program）框架内的常规风险因素评估与心血管疾病预防工作基础上开展。 本研究共纳入3500名心血管疾病低/中度风险的健康受试者，对其实施颈动脉超声检查，并按随机原则分为两组。干预组的受试者及其主治医生可获取受试者亚临床动脉粥样硬化的彩色图文信息；对照组则不获得任何超声检查结果相关内容。分别于随访第1、3及6.5年时，开展临床风险因素样本采集、用于生物标志物（biomarker）分析的血液样本采集，并实施全面问卷调查与访谈。 在随访第3年及第6.5年时，将再次开展超声检查，并向所有受试者及其主治医生告知检查结果。本数据库还涵盖预防性药物处方登记数据、空气污染物暴露数据、VIPVIZA项目启动前10年及20年的健康检查数据，以及男性应征入伍相关数据。 在随访满10年后，将收集终点事件、心血管疾病发病率与死亡率的登记数据。 如需获取VIPVIZA的数据门户及该项目的研究数据，可与VIPVIZA项目内的研究人员开展合作。如需进一步咨询，请联系项目负责人乌尔夫·纳斯隆德（Ulf Näslund），邮箱：[e-mail] 用于评估与心血管疾病发生发展密切相关的心理因素的经验证问卷，示例包括：健康素养、焦虑/抑郁状态、应对机制、一般自我效能感、压力/职业倦怠、乐观/悲观倾向、自评心血管疾病风险、职业倦怠。 此外还包括：自评心血管疾病风险、特定领域自我效能感、生活习惯态度。 干预组相关内容：超声报告的受试者反应及其影响。