Enantioselective Construction of Spirooxindole-Fused Cyclopentanes
收藏Figshare2021-07-20 更新2026-04-28 收录
下载链接：
https://figshare.com/articles/dataset/Enantioselective_Construction_of_Spirooxindole-Fused_Cyclopentanes/15023490
下载链接
链接失效反馈官方服务：
资源简介：
The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high diastereoselectivities. The synthetic utility of the protocol was exemplified on a set of additional transformations of the corresponding spiro compounds. In addition, a study showing the promising biological activity of selected enantioenriched products was accomplished.
创建时间：
2021-07-20
