Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes_Muscle. Mus musculus

Transcriptional profiling of muscle and liver samples from muscle- and liver-specific AIF knockout mice respectively. Samples obtained from 8 week old, male knockouts, backcrossed 8 times onto the C57Bl6 background are compared to those obtained from littermate control mice. Keywords: disease state analysis, AIF knockout, metabolism Overall design: For the muscle experiment single samples from three different knockout mice are compared with samples fom three independent control mice. For the liver experiment samples are obtained from 4 liver AIF knockouts and compared with a pooled sample obtained from 4 different control mice.