Computational design and improvement of a broad influenza virus HA stem targeting antibody. Duan et al.

Design functional antibodies against the stalk region of hemagglutinin through computer-aided design. Top-designed M18.1.2.2 enhances performance both in vitro and in vivo.本研究通过计算机辅助设计策略，针对血凝素（hemagglutinin）茎区设计功能性抗体。 优选得到的设计变体M18.1.2.2可在体外与体内均提升性能表现。