CONTROLLED RELEASE KINETICS OF 6-BENZYLAMINOPURINE DERIVATIVES FROM A HYDROGEL MATRIX

Controlled delivery of biologically active compounds is an essential requirement for modern regenerative veterinary materials. In this study, the release kinetics of 6-benzylaminopurine (BAP) derivatives from a biocompatible hydrogel matrix was investigated. The hydrogel carrier was prepared from natural polymer components using ionic crosslinking to obtain a three-dimensional porous network capable of retaining water and gradually releasing the active compound. The incorporation of BAP derivatives into the matrix was carried out during gel formation to achieve uniform distribution and prevent rapid diffusion from the wound surface. Physicochemical characterization showed high swelling capacity and stable structural integrity of the hydrogel under physiological conditions. Release experiments performed in buffer medium at body temperature demonstrated a biphasic profile consisting of an initial moderate release followed by a prolonged diffusion-controlled stage. The release behavior corresponded to non-Fickian transport, indicating combined diffusion and polymer relaxation mechanisms. Mathematical modeling confirmed sustained liberation of BAP derivatives over an extended period, maintaining therapeutically relevant concentrations. The obtained results suggest that immobilization of 6-benzylaminopurine derivatives in a hydrogel matrix provides controlled and prolonged delivery, which is beneficial for regenerative applications and reduction of repeated topical treatments in veterinary practice.