cryo-EM structure of GPR6-Gs-Nb35 complex
收藏Protein Data Bank Japan2025-05-21 更新2026-04-19 收录
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cryo-EM structure of GPR6-Gs-Nb35 complex Descriptor: G-protein coupled receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Barekatain, M, Johansson, L.C, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, J, Hua, T, Katritch, V, Cherezov, V. Deposit date: 2023-08-26 Release date: 2024-12-04 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease. Sci.Signal., 17, 2024
GPR6-Gs-Nb35复合物的冷冻电镜（cryo-EM）结构
描述符：G蛋白偶联受体6（G-protein coupled receptor 6）、鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）、鸟苷酸结合蛋白G(I)/G(S)/G(T)亚基β-1（Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1）……
作者：Barekatain, M、Johansson, L.C、Lam, J.H、Sadybekov, A.V、Han, G.W、Popov, P、Russo, J、Bliesath, J、Brice, N、Beresford, M、Carlson, L、Saikatendu, K.S、Sun, H、Murphy, S、Monenschein, H、Schiffer, H.H、Lutomski, C、Robinson, C.V、Liu, J、Hua, T、Katritch, V、Cherezov, V
存档日期：2023-08-26
发布日期：2024-12-04
最后修改日期：2025-05-21
实验方法：电子显微镜（分辨率3.43埃）
引用文献：《与帕金森病相关的孤儿受体GPR6高基础活性与反向激动作用的结构洞察》，《Science Signaling》，第17卷，2024年
创建时间：
2023-08-26
