Heterogeneity and the effect of moderators on heterogeneity for overall and clinical feature-specific case fatality rates in descriptive studies of severe Plasmodium falciparum malaria.

NS, No statistically significant contribution to overall heterogeneity; Def, Definition; *, ** and ***, P-valuesaIncludes 7 studies where overall case fatality rates are calculated according to treatment regimen.bIncludes 9 studies where case fatality rates due to deep coma are calculated separately according to treatment regimen.cChildren with overlapping syndrome comprising coma, severe anemia and any of: metabolic acidosis, respiratory distress or hyperlactatemia.