BIG3

BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden. As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort. Ultimately, the study aims to find out which individuals that are at greater risk of developing one or more of the three diseases and why some individuals seem to be protected. Purpose: BIG3 aims to increase understanding and to reduce morbidity / mortality in chronic diseases such as COPD, lung cancer and cardiovascular diseases, and to improve the care and quality of life for individuals with these disorders.BIG3是一项斯科讷（Scania）地区的研究项目，名称“BIG3”指代三大疾病：慢性阻塞性肺疾病（COPD）、心血管疾病与肺癌。本项目的总体目标是阐明上述三类疾病的发病机制，进而开发全新治疗手段，以实现更早、更精准且更优质的诊断，最终为患者提供更具个体化的治疗方案。BIG3是瑞典开展的一项开放型前瞻性纵向队列研究。 首期招募环节中，斯科讷地区约10万名年龄介于45至75岁的民众将有机会填写涵盖生活方式、居住环境与烟草使用习惯的调查问卷。后续将从完成问卷的应答者中遴选约10000名个体接受专项检查，项目包括心电图（ECG）、心肺CT扫描、肺功能检测与血液检验。血液样本将分两部分处理：一方面针对多项生物标志物开展即时分析，另一方面将存入生物样本库以供后续研究使用。本研究力争使队列中的吸烟者占比达到约50%。 本研究的最终目标是明确哪些个体罹患上述三种疾病中一种或多种的风险更高，并解析为何部分个体可免受此类疾病的侵扰。 研究宗旨：BIG3旨在加深对慢性疾病（如COPD、肺癌与心血管疾病）的认知，降低此类疾病的发病率与死亡率，并改善此类疾病患者的诊疗水平与生活质量。