Chemical Genetics of TOR Identifies an SCF Family E3 Ubiquitin Ligase Inhibitor
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA128719
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资源简介：
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyper-activation of the mTOR pathway in human cancers, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based high-throughput chemical genetic screen to identify small-molecule enhancers of rapamycin (SMERs) and used whole genome expression analysis to identify their mechanisms of action. This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
创建时间：
2011-06-30
