Replication Data for: Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells (supplementary data)
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https://rdr.kuleuven.be/citation?persistentId=doi:10.48804/VWGS9V
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资源简介：
Datasets that support the supplementary figures published in Sneyers et al, Cell Death and Disease (2023). The project aims to decipher how BAPTAi limits the survival of B-cell cancers, more specifically by its Ca2+-independent effects. We can conclude from these data that BAPTAi inhibits the activity of the glycolytic enzyme PFKFB3, thereby deactivating mTORC1-driven translation, resulting in MCL-1 downregulation. As a consequence, BAPTAi treatment results in cell death in MCL-1 dependent cancers. (2023-08-24)
提供机构：
KU Leuven RDR
创建时间：
2023-09-12
