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Transcriptomic Responses of Laser Capture Microdissected Nephrons from Rat Kidneys Exposed to Single administration of 5 mg/kg Cisplatin: 29 days study - second technical replicate of the RNA sequencing

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/ERP139978
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资源简介:
The data contains the transcriptomic responses of the nephron segments (CPT: cortical proximal tubules and PPT: perimedular proximal tubules) of the rat kidneys exposed to single administration of cisplatin i.v. 5 mg/kg for 29 days (1, 3, 5, 8, 10, 12, 15, 20, 28 days of collection times). The kidneys were fixed with formaldehyde and embedded in paraffin followed by sectioning for 8 um thickness and staining with hematoxylin and eosin staining. The nephron segments were collected using laser capture microdissection microscope for targeted RNA sequencing purposes. The whole kidneys were taken along for the comparison. This RNAseq outcomes suggest different temporal dynamics of transcriptomic responses elicited in different nephron segments upon cisplatin exposure. This RNA-seq outcomes is the first technical replicate of the RNA sequencing to replace low quality samples from the first replicate. This is part of the TransQST project.
创建时间:
2025-07-18
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