Sequence-Dependent Persistence Length of Long DNA
收藏DataCite Commons2022-03-08 更新2025-04-09 收录
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https://conservancy.umn.edu/handle/11299/191753
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资源简介：
Using a high-throughput genome-mapping approach, we obtained circa 50 million measurements of the
extension of internal human DNA segments in a 41 nm × 41 nm nanochannel. The underlying DNA
sequences, obtained by mapping to the reference human genome, are 2.5–393 kilobase pairs long and
contain percent GC contents between 32.5% and 60%. Using Odijk’s theory for a channel-confined
wormlike chain, these data reveal that the DNA persistence length increases by almost 20% as the percent
GC content increases. The increased persistence length is rationalized by a model, containing no adjustable
parameters, that treats the DNA as a statistical terpolymer with a sequence-dependent intrinsic persistence
length and a sequence-independent electrostatic persistence length.
提供机构：
Data Repository for the University of Minnesota (DRUM)
创建时间：
2017-12-11
