Crystal Structure of the Metallo beta-Lactamase from Bacteroides fragilis (CfiA) in Complex with the Tricyclic Inhibitor SB-236050.

Crystal Structure of the Metallo beta-Lactamase from Bacteroides fragilis (CfiA) in Complex with the Tricyclic Inhibitor SB-236050. Descriptor: 7,8-DIHYDROXY-1-METHOXY-3-METHYL-10-OXO-4,10-DIHYDRO-1H,3H-PYRANO[4,3-B]CHROMENE-9-CARBOXYLIC ACID, SODIUM ION, ZINC ION, ... Authors: Payne, D.J, Hueso-Rodrguez, J.A, Boyd, H, Concha, N.O, Janson, C.A, Gilpin, M, Bateson, J.H, Cheever, C, Niconovich, N.L, Pearson, S, Rittenhouse, S, Tew, D, Dez, E, Prez, P, de la Fuente, J, Rees, M, Rivera-Sagredo, A. Deposit date: 2002-01-08 Release date: 2003-01-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases ANTIMICROB.AGENTS CHEMOTHER., 46, 2002

脆弱拟杆菌（Bacteroides fragilis）来源的金属β-内酰胺酶（Metallo beta-Lactamase，CfiA）与三环类抑制剂SB-236050复合物的晶体结构。
描述物：7,8-二羟基-1-甲氧基-3-甲基-10-氧代-4,10-二氢-1H,3H-吡喃并[4,3-b]色烯-9-羧酸、钠离子、锌离子……
作者：Payne, D.J、Hueso-Rodríguez, J.A、Boyd, H、Concha, N.O、Janson, C.A、Gilpin, M、Bateson, J.H、Cheever, C、Niconovich, N.L、Pearson, S、Rittenhouse, S、Tew, D、Dez, E、Prez, P、de la Fuente, J、Rees, M、Rivera-Sagredo, A。
保藏日期：2002-01-08
发布日期：2003-01-08
最后修改日期：2023-08-16
实验方法：X射线衍射（2.5埃）
引用文献：《一系列三环天然产物作为强效广谱金属β-内酰胺酶抑制剂的鉴定》，《抗微生物剂与化学治疗（Antimicrobial Agents and Chemotherapy）》，第46卷，2002年