Genome-wide chromatin profiling using ATAC-seq of diabetic or non-diabetic murine haematopoietic stem cells (HSC)
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=d3013b3348ad616230558ee5f469377f
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资源简介：
To understand the underlying mechanisms and predict transcription factors implicated in the generation and sustained pro-inflammatory memory within HSCs, ATAC-seq was performed on bone marrow HSCs isolated from either diabetic or non-diabetic control mice. Differential peak analyses indicated that cells form diabetic mice had an altered chromatin structure, and pathway analysis of these differential sites revealed pathways associated with inflammation. Peak motif enrichment analysis implicated Runt-related transcription factor 1 (RUNX1), among others, to be significantly enriched.
提供机构：
University of Oxford
创建时间：
2022-02-20
