pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7)

pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7) Descriptor: N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... Authors: Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. Deposit date: 2014-08-27 Release date: 2014-09-10 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014

该复合物为pVHL:EloB:EloC与(2S,4R)-1-((S)-2-乙酰氨基-3,3-二甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-甲酰胺（配体7）的结合体。描述符：N-乙酰基-3-甲基-L-缬氨酰-(4R)-4-羟基-N-[4-(4-甲基-1,3-噻唑-5-基)苄基]-L-脯氨酰胺；转录延伸因子B多肽1（Transcription elongation factor B polypeptide 1）、转录延伸因子B多肽2（Transcription elongation factor B polypeptide 2）等。作者：Gadd, M.S.、Soares, P.、Galdeano, C.、van Molle, I.、Ciulli, A.。提交日期：2014-08-27；发布日期：2014-09-10；最后修改日期：2024-10-23。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.1 Å。引用文献：《靶向Von Hippel-Lindau（VHL）E3泛素连接酶（E3 Ubiquitin Ligase）与缺氧诱导因子（Hypoxia Inducible Factor, HIF）α亚基之间蛋白-蛋白相互作用的小分子化合物的结构导向设计与优化：体外纳摩尔级亲和力》，发表于《Journal of Medicinal Chemistry》（J.Med.Chem.），2014年，第57卷。