Diabetes Prediction in Scania - DiPiS

Diabetes Prediction in Scania (DiPiS) aims to determine why children develop type 1 diabetes. By being able to predict which children are at risk of developing diabetes, the hope is to prevent the onset of the disease in the future. DiPiS was conducted in two stages: Stage 1: Examination of the hereditary risk for type 1 diabetes in all newborns in Scania. This stage took place from September 2000 to September 2004. During this stage, almost 36,000 children were examined. Stage 2: Follow-up of a group of children with hereditary risk. Approximately 5,000 children were followed. Participants in the follow-up study provided blood samples once a year and also completed a questionnaire. Children with multiple antibodies are at an increased risk of developing type 1 diabetes and were therefore monitored more frequently. The children were followed until the age of 15. Objective: To determine factors that can predict autoimmune (type 1) diabetes in children.斯堪尼亚地区糖尿病预测研究（Diabetes Prediction in Scania，简称DiPiS）旨在探究儿童罹患1型糖尿病（type 1 diabetes）的致病机制。通过精准识别存在糖尿病发病风险的儿童，有望在未来阻断该疾病的发生发展。该研究分为两个阶段开展： 第一阶段：对斯堪尼亚地区所有新生儿开展1型糖尿病遗传风险筛查。本阶段于2000年9月至2004年9月期间实施，共完成近36000名儿童的筛查检测。 第二阶段：对携带遗传风险的儿童群体进行长期随访。本阶段共纳入约5000名儿童参与随访。参与随访的受试者每年采集一次血液样本，并完成相关调查问卷。体内存在多种抗体的儿童罹患1型糖尿病的风险更高，因此对该类群体采取了更为频繁的监测方案。所有随访儿童的观察周期均持续至其15周岁。 研究目标：明确可用于预测儿童自身免疫性（1型）糖尿病的相关影响因素。