Time series gene expression in critically ill patients: PREVAIL study

The PREVAIL study was a Phase II/III randomized controlled trial examining the use of lactoferrin to prevent nosocomial infections in critically ill patients undergoing mechanical ventilation. Gene expression data was generated from a consecutive subset of patients at the lead study site. We used the Affymetrix PrimeView array to generate expression data at various time points during the ICU stay. Time series gene expression profiling of critically ill patients undergoing mechanical ventilation, who were enroled in the PREVAIL study