Additional file 2: of Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids

Table S1. OTUs with differential abundances between samples of healthy dogs and dogs with CE at day 0 (Healthy vs CE day 0). Table S2. OTUs with differential abundances between day 0-samples of diet responsive dogs and non-diet responsive dogs. Table S3. Genera with differential abundances between samples of day 14 and day 0 (day 14 versus day 0) for diet responsive dogs. Table S4. OTUs with differential abundances between samples of day 14 and day 0 for diet responsive dogs (day 14 versus day 0). Table S5. OTUs with differential abundances between samples of day 14 and day 0 (day 14 versus day 0) for non-diet responsive dogs. Table S6. Differentially abundant pathways between day 14 and day 0 after diet treatment from metagenomic analysis for diet-responsive dogs (fold-change > 1.5 and P-value < 0.05). Table S7. Comparisons of bile acids in samples at different timepoints for diet responsive dogs. Table S8. Spearman correlations between abundance of OTUs and concentration of Bile acids in diet responsive dogs. Table S9. Spearman correlations between bile acids and bile salt hydolases (BSHs) in diet-responsive dogs (P < 0.05). (XLSX 135 kb)表S1：健康犬与0天时慢性肠病（Chronic Enteropathy，CE）犬样本间丰度存在差异的操作分类单元（Operational Taxonomic Units，OTUs）（健康组 vs CE组 0时样本）。表S2：日粮响应型犬与非日粮响应型犬的0天样本间丰度存在差异的OTUs。表S3：日粮响应型犬的第14天与第0天样本间丰度存在差异的菌属（第14天 vs 第0天）。表S4：日粮响应型犬的第14天与第0天样本间丰度存在差异的OTUs（第14天 vs 第0天）。表S5：非日粮响应型犬的第14天与第0天样本间丰度存在差异的OTUs（第14天 vs 第0天）。表S6：日粮响应型犬经日粮治疗后，通过宏基因组分析得到的第14天与第0天样本间的差异丰度通路（倍数变化>1.5且P值<0.05）。表S7：日粮响应型犬不同时间点样本中的胆汁酸对比分析。表S8：日粮响应型犬中OTU丰度与胆汁酸浓度间的斯皮尔曼（Spearman）相关性。表S9：日粮响应型犬中胆汁酸与胆汁盐水解酶（Bile Salt Hydrolases，BSHs）间的斯皮尔曼相关性（P<0.05）。（XLSX格式，文件大小135 KB）